Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats.
The clinical significance of these findings is unknown.
[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.
BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.Physicians and pharmacists are responsible for fully educating patients about the risks of sedating antihistamines from pharmacological points of view.If a sedating antihistamine must be prescribed, its sedative effects should be thoroughly considered before choosing the drug.Dosing:: one tablet twice daily for adults and children 12 years of age and older (should be taken on an empty stomach).A dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function.Please see package insert for additional information and possible updates.The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.Desloratadine inhibited histamine release from human mast cells in vitro.Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.Dosage - Oral: Children 6-11 years: 30 mg twice daily Children /= 6 years and Adults: 10 mg once daily Elderly: Peak plasma levels are increased; elimination half-life is slightly increased; specific dosing adjustments are not available Dosage adjustment in renal impairment: Clcr /= 6 years and Adults: 10 mg every other day Supplied Syrup (Claritin®): 1 mg/m L (120 m L) [contains sodium benzoate; fruit flavor] Tablet (Alavert™, Claritin®, Claritin® Hives Relief; Tavist® ND): 10 mg Tablet, rapidly-disintegrating: 10 mg Alavert™: 10 mg [contains phenylalanine 8.4 mg/tablet] Claritin® Redi Tabs®: 10 mg [mint flavor] Dimetapp® Children's ND: 10 mg [contains phenylalanine 8.4 mg/tablet] (pseudoephedrine 120mg fexofenadine 60mg).