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Normally, females have two X chromosomes; however, females with trisomy X carry three X chromosomes in the nuclei of body cells.

There are specific physical features (phenotype) associated with this chromosomal disorder.

Common symptoms that can potentially occur include language-based learning disabilities, developmental dyspraxia, tall stature, low muscle tone (hypotonia), and abnormal bending or curving of the pinkies toward the ring fingers (clinodactyly).

Trisomy X occurs randomly as a result from errors during the division of reproductive cells in one of the parents.

It was filmed in Colombia during May and June 2017, with alumni from Real World, Road Rules, The Challenge, and Are You the One? Jonathan Murray, Gil Goldschein, Scott Freeman, and Fred Birckhead were the executive producers, with Ryan Smith and Danny Wascou serving as co-executive producers.

A launch special aired on July 11, 2017, and the season premiered on July 18, 2017. Lavin will announce to each contestant as to whether a challenge will be declared as either an individual, pair or team challenge.

It is important to note that affected individuals may not have all of the symptoms discussed below.

However, reports indicate that some affected females may have abnormal development of the ovaries (ovarian dysgenesis) and/or the uterus; delayed puberty or early onset of puberty (precocious puberty), and/or fertility problems.Intervention should be initiated earlier so that the girls do not experience repeated exposure to failure.Some infants with trisomy X may have mild facial abnormalities including vertical skin folds that may cover the eyes’ inner corners (epicanthal folds), widely spaced eyes (hypertelorism), and smaller than normal head circumference.Trisomy X is often associated with neurodevelopmental differences and language-based learning disabilities. IQ may be 10-15 points below that of siblings or control groups if early intervention has not been successful or begun early enough.Infants and children with trisomy X experience delays in attaining developmental milestones, especially in the acquisition of motor and speech skills.Girls with trisomy X have an increased frequency of language-based learning disabilities including reading deficiencies such as dyslexia, reading comprehension deficits and/or reading fluency issues in conjunction with other language-based disabilities.They also have developmental dyspraxia which affects learning in every domain.Some females may have no symptoms (asymptomatic) or very mild symptoms and may go undiagnosed.Other women may have a wide variety of different abnormalities.Early detection and treatment are very beneficial for girls with trisomy X.In many cases, these girls have few issues later in life when identified early and treated appropriately.

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